Leeds are 16th, but their most recent league fixture was a critical 3-1 win over Burnley which has them five points clear of the relegation zone.
Defender Kurt Zouma returned to training ahead of a schedule following a hamstring injury and he faces a late fitness test.
Patrick Bamford has been battling ankle hip injuries, but the Whites are hopeful he can play a part in this contest.
West Ham United: Fabianski; Cresswell, Diop, Dawson, Coufal; Masuaku, Lanzini, Rice, Fornals, Bowen; Antonio
Leeds United: Meslier; Firpo, Struijk, Koch, Ayling; Dallas, Forshaw; Harrison, Klich, Raphinha; Bamford
Ones to watch
Jarrod Bowen (West Ham United)
The pacy forward has been the Hammers best player. scoring eight goals and assisting on eight others while consistently putting in solid performances.
The £22m paid to Hull City looks to be a bargain for a player that will be in the England international squad sooner rather than later.
Raphinha (Leeds United)
Subject of much transfer talk due to his outstanding play, the Whites will be keen to hold onto the Brazilian, especially in the face of the club continuing to play with a shorthanded side.
The two sides met just last week in the third round of the FA Cup with West Ham emerging 2-0 winners.
Leeds were unhappy as they felt Bowen was offside in the build-up, but the goal was upheld after a lengthy VAR check.
Bowen and Fredericks both then went close to doubling the Hammers advantage before the former Hull man sealed the match on the counter in the third minute of injury time.
The match will be broadcast live in the UK by Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HD.
Kick-off is set for 2pm UK time.