Liverpool held on to secure a 2-1 aggregate win after their sensational performance at the San Siro.
Here are the key takeaways from the round of 16 second-leg clash.
Anfield unbeaten run over
The Argentinian's stunning strike ended the Reds 28-game unbeaten streak at Anfield.
It was a year and a day since a 1-0 defeat to Fulham marked their sixth consecutive home loss.
It also brought the Reds impressive winning-streak (12 games in all competitions) to a grinding halt.
However, manager Jurgen Klopp was not too disappointed with the result after the game.
"The art of football is to lose the right games. If there was any game we could have afforded to lose it was tonight, because the main target of this competition is to get through," he said.
We know all too well about the danger Trent Alexander-Arnold poses in attacking areas, however, he has often been criticised for the defensive side of his game.
Tonight's performance showed that his manager's defence of his defending after the win over West Ham was justified.
After Saturday's game, Klopp said that he did not understand the criticism of his right-back's defensive abilities.
"If he couldn’t defend, he would not play here – at least not that in that position," he added.
Against Inter, the 23-year-old won five of six duels, made nine ball recoveries and three tackles/interceptions.
He even nearly scored, with a stunning free-kick effort curling just wide of Samir Handanovic's left post.
The Egyptian has failed to score in his last three starts but had chances to break that mini-drought.
He hit the post twice but was upbeat about it after the game.
"I hit the post twice but it's ok. Maybe next game I can score three," he joked to BT Sport.
Maybe he is need of a break after his exploits at the Africa Cup of Nations.
Jones takes his chance
Curtis Jones provided his manager with a selection dilemma at a crucial point in the Reds season.
He was given a surprise start and he did not disappoint with a mature performance against a top side.
The 21-year-old was subbed off after 65 minutes after a solid display.
He won four of his six duels, made five ball recoveries and completed 93% of his passes.
However, he seems to be back in favour for the business end of the season.
A rubbish referee?
That was not the case tonight.
The worst decision was a first-half yellow card for Alexis Sanchez after he had caught Thiago Alcantara in the knee.
Klopp echoed these sentiments post-match.
"He was quite lucky he didn’t get a different colour for that foul... Passion is good, but if it leads to those things, it doesn’t help," he said.
This tweet from a Manchester City writer sums up Antonio Mateu Lahoz's performance.
Liverpool are through to the quarter-finals, ultimately that is all that matters.
The performance was not the best but they still restricted Inter to 0.26 xG whilst having 1.87 themselves.
Teams will be hoping to avoid Klopp's men when the draw takes place on March 18th.