Both sides head into the fixture off the back of some impressive results as United recently defeated AC Milan 2-1 on aggregate in the Europa League while the Foxes demolished Sheffield United 5-0 in the Premier League.
Brendan Rodgers will certainly be aware of the threat United pose in attack, making this crunch fixture a big challenge for the Foxes defence. However, with Wesley Fofana, Jonny Evans, and Çağlar Söyüncü all fit and back in the first team, the Leicester manager will have his strongest choices available.
United manager Ole Gunnar Solskjaer will likely play the 4-2-3-1 formation that has served him well in recent games. With Victor Lindelof and former Fox Harry Maguire remaining as the team's defensive partnership, Jamie Vardy and Kelechi Iheanacho will need to continue their impressive link-up play to get past the United defence.
As United's top goalscorer and leader in assists, Bruno Fernandes will need to be the main dangerman Leicester lookout for. With 23 goals and 13 assists in 44 games, the attacking-midfielder has proved to be one of the most impacting players in the league and could once again cause trouble for the Foxes.
Wilfred Ndidi will most likely face the task of containing Fernandes, with the defensive midfielder's expertise being in regaining possession and eliminating the danger to the defence.
Whilst this vital battle in midfield takes place, it may be Leicester's left flank that undergoes the most challenging test.
As the left centre-back, Söyüncü could have the exhausting task of containing United winger Daniel James throughout the match. The defender has the strength to contest with James but the winger's speed and skill on the ball could be a dangerous weapon.
On the right side for Leicester, there will be an essential battle with the in-form left-back Luke Shaw, who has recaptured his form in an outstanding season for the Red Devils. Shaw's ability to break forward and deliver crosses to the waiting forwards has been a valuable tool for Solskjaer this season.
As right-wing-back Ricardo Pereira will miss the fixture due to a hamstring issue, the Foxes may need Daniel Amartey to return to the starting side to add some physicality to the Leicester team and challenge Shaw's attacking runs.
Set piece danger
Although there will be several important battles across the pitch, the deciding factor of this fixture could be set-pieces.
Leicester's poor set-piece defensive record could once again be their Achilles heel as United have the areal power to punish the Foxes' weakness.
Maguire may become his former club's biggest problem, as his dominance in the air and powerful heading ability could be a dangerous weapon for United's set-pieces.
The possible absence of striker Edinson Cavani due to injury could be a massive boost for Rodgers' side as the forward's aerial threat could have been a challenge for the Leicester defence.
Marcus Rashford may also miss the FA Cup fixture after picking up an injury in United's Europa League match with Milan, leaving Solskjaer without his second-highest goalscorer.
Despite this, Foxes in-form goalkeeper Kasper Schmeichel will certainly be kept busy during the game as he aims to keep his second successive clean-sheet.
With both sides in impressive forms, this fixture is likely to be an exciting clash.