Tranmere will be looking to record their first win in four games with Scunthorpe hoping to edge clear of any lingering late relegation woes.
Scunthorpe goalkeeper Mark Howard will again miss out through a persisting thigh strain, with Devarn Green also falling to the same fate.
Jai Rowe could partner Jacob Bedeau at centre back with fellow defender George Taft currently injured and nearing a return to full fitness following a return to training this week.
Club-captain Jordan Clarke is also a doubt with an ankle injury.
As for the visitors, midfielder Jay Spearing will miss out after limping off on in Monday's draw with Cambridge United.
James Vaughan also still remains out following a lengthy knee injury and looks unlikely to feature before the end of the campaign.
Scott Davies is also sidelined with a long term achilles injury.
Scunthorpe United - 4-4-2
Watson; O'Malley, Rowe, Bedeau, Howe; Hippolyte, Spence, Karacan, Gilliead; Loft, Eisa.
Tranmere Rovers - 4-4-1-1
Murphy; Khan, Clarke, MacDonald, Monthe; Lloyd, O'Connor, Morris, Blackett-Taylor; Lewis; Woolery.
Ones to watch
Alex Gilliead - Scunthorpe United
Stand-in captain in the absence of Jordan Clarke, Alex Gilliead has been a consistent performer in Neil Cox's side this season, and is always one to keep an eye on in any given fixture. With superb trickery and terrific ball retention particularly in tight spaces, Gilliead provides a crucial out ball whenever Scunthorpe look to turn defence into attack.
Corey Blackett-Taylor - Tranmere Rovers
Corey Blackett-Taylor is certainly one for Scunthorpe to keep an eye on should he be given the nod this weekend, with the ex-Aston Villa youngster looking to make an impression within the EFL following his move in June 2019. With explosive pace and an eye for a killer pass, Blackett-Taylor provides a strong threat when in attacking areas and is a key asset to this Rovers side.
It was Tranmere who came out on top in this seasons previous meeting, with James Vaughan netting twice at Prenton Park to seal all three points for then Rovers manager, Mike Jackson.
Due to current restrictions in the UK, there will be no fans in attendance at Prenton Park. However, the game is available to watch on both club's iFollow platforms. Kick-off is at 15:00 BST.