Tottenham were defeated by Brighton last time out, stopping a run of four consecutive wins. Spurs are battling Arsenal, Manchester United and West Ham United for a place in next season's Champions League.
Matthias Zanka has been ruled out for the remainder of the season with an adductor issue.
Brentford: Raya; Henry, Sørensen, Jansson, Ajer; Eriksen, Nørgaard, Janelt; Wissa, Toney, Mbeumo
Tottenham Hotspur: Lloris; Davies, Dier, Romero; Sessegnon, Højbjerg, Bentancur, Royal; Son, Kane, Kulusevski
Ones to watch
Christian Eriksen (Brentford)
Just getting onto the pitch has made his return to action following his cardiac arrest for Denmark at last year's Euros successful, but his immense talent and ability to contribute, with a goal and two assists in his last four games, make this the story of the top-flight season.
The Bees have won all five games Eriksen has started, a statistic that should surprise no one.
Harry Kane (Tottenham Hotspur)
Always the focus of the opposing defense, Kane didn't score in the reverse fixture, making Brentford the only one of the 32 Premier League opponents he has faced he has not found the back of the net against.
He's been particularly effective in London derbies, registering 50 points, trailing only Thierry Henry in that category.
In December, Tottenham defeated Brentford 2-0 to win back-to-back league matches under Antonio Conte for the first time.
The South Korean could have extended the hosts' lead with a 20-yard shot if not for a spectacular save by Fernandez.
Tottenham did find a second off of a counter-attack. Kane played in Sergio Reguilon down the left-hand side and his ball across the face of goal was tapped in by Son.
The match will be televised by Sky Sports Main Event with kick-off set for 5:30pm UK time.