They will however face stiff competition in a Toon side that have remained unbeaten at St James' Park in 2022, winning six in a row at their fortress for the first time since 2003 under Sir Bobby Robson.
This gives The Magpies full hope they can provide a shock to proceedings and therefore give a helping hand to Manchester City
Howe commanding Newcastle out of a relegation battle and into mid table security, whereas Klopp has taken Liverpool to a stage where they could potentially win the quadruple.
This particular feat has landed the German a new two year deal at the Reds.
Team News - Newcastle
Newcastle go into this fixture with no fresh injury woes but instead look to their physio table to see long-term absentees Callum Wilson and Kieran Trippier who have both been sidelined for several months. Both, however, edge closer to a return and should walk onto the field of a Premier League game again this season.
Instead Howe faces a selection headache with many players in form. He rotated against Norwich City and saw his side sweep the Canaries aside in a complete performance. This will give Howe food for thought as he questions to reward those who came into the side with a second start in a row or to revert back to his old faithful.
Team News - Liverpool
Liverpool will have to travel without Brazilian, Roberto Firmino, after he picked up a foot injury which has ruled him out of the past three games.
On top of this there are doubts over the availability of English Midfielder, Curtis Jones and Greek international Kostas Tskimkas, both suffering from a virus but could yet return to action in time for Saturday's encounter.
Last time out saw an exciting start to the game with a Newcastle counter attack giving the visitors the lead with a smart Jonjo Shelvey finish in front of the Kop on his return to Anfield.
What followed however was a Liverpool onslaught as they found an equaliser just 13 minutes later with a controversial finish from Diogo Jota. Mohammed Salah then did what Mohammed Salah does as he takes advantage of a Shelvey mistake, firing home a rebound from a Sadio Mane shot that was saved by Martin Dubravka.
Newcastle remained on the back foot and conceded the game ender as Trent Alexander-Arnold scored a wonderful goal from the edge of the area to wrap up the three points.
You can find highlights from the encounter below.
Ones to watch
Newcastle - Bruno Guimaraes
His ability to win the ball back but also cause a threat going forward, proven by his three goals and an assist in the past three games, has caught the eye of the Premier League and supposedly European giants, Real Madrid. With him facing a notoriously tough Liverpool midfield it will be interesting to see how he fairs against some of the world's best.
Liverpool - Luis Diaz
Another January addition to the Premier League, the columbian, Luis Diaz, has set the league alight with his pace and flair. He continues to impress as his fearlessness to attack the opponents makes him an exhilarating player to watch.
It's unsure whether he will start in this game but he's bound to make an appearance and make a difference. He's grabbed three in all competitions for Liverpool to compliment his two assists already in Red.
Newcastle: Dubravka, Krafth, Schar, Burn, Targett, Murphy, Guimaraes, Shelvey, Joelinton, Saint-Maximin, Wood
Liverpool: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Thiago, Keita, Salah, Jota, Mane
Where to watch?
This game is a 12:30 kick off on Saturday meaning the game is available to watch live on BT Sport, with highlights available shortly after full-time on YouTube.