Liverpool take on Newcastle with Anfield still on cloud nine after last weekend’s victory over Bournemouth.
The Reds ran riot with seven different scorers against the Cherries, the perfect tonic for their poor start to the season.
Defeat to Manchester United and draws with Crystal Palace and Fulham have left Jurgen Klopp’s side in a tricky position in the title race.
They will hoping to gain momentum ahead of a trip to local rivals Everton on Saturday.
The visitors have started the season unbeaten with a victory over newly-promoted Nottingham Forest on the opening day followed by draws with Brighton, Manchester City and Wolves.
In that draw with City they took the lead twice, with the Reds recent record of conceding first (before the weekend's win, they had conceded first in their last seven PL games) it could be down to whichever team starts faster.
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Team News
Darwin Nunez will serve the last match of his suspension for his headbutt on Joachim Andersen.
Harvey Elliott was substituted at half-time in the win over Bournemouth as a precaution and therefore should be able to feature.
Klopp confirmed that the clash will come too soon for Diogo Jota, who will return to training on Thursday.
However, Joel Matip and Curtis Jones are back in training and may be in contention to feature.
Thiago Alcantara is still out but should return in the next few weeks.
Ibrahima Konate, Naby Keita, Alex Oxlade-Chamberlain and Calvin Ramsay are still absent.
Callum Wilson, Allan Saint-Maximin and Bruno Guimaraes are all likely to be ruled out of the contest.
The club are sweating on a work permit for new signing Alexander Isak, but he will travel as the deadline is 75 minutes before kick-off.
"I still don't know, I desperately hope so,” was the response of Eddie Howe when asked about the matter.
Jonjo Shelvey and Emil Krafth will also miss out.
Likely lineups
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Elliott, Fabinho, Henderson; Salah, Firmino, Diaz
Newcastle: Pope; Trippier, Schar, Botman, Burn; Willock, S Longstaff, Joelinton; Almiron, Wood, Fraser
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Key Players
Liverpool- Mohamed Salah
Salah somehow did not manage to get on the scoresheet in a 9-0 win, leading to many Fantasy Premier League players taking him out of their squads for this game week.
A staggering 519,264 users have transferred him out of their official PL fantasy football teams.
However, that is a big risk, as the Egyptian will be determined to ensure that he is not left behind in the Golden Boot race after an Erling Haaland hat-trick and a Harry Kane brace at the weekend.
Salah has scored two, whilst Tottenham's Kane has four and Man City's Haaland has six already.
He has scored in all five of his Premier League home matches against the Magpies for the Reds.
He will be hoping to hit Newcastle for six on Wednesday evening.
Newcastle- Sven Botman
With Saint-Maximin, Wilson, Guimaraes and potentially Isak likely to be absent, Newcastle have a lot of work to do on the attacking front.
However, staying solid at the back against a Liverpool side that scored nine in their last outing is just as important.
The Dutchman is still settling on Tyneside, this might be his hardest task yet though.
His performance against Wolves came in for some criticism with Lee Ryder from Chronicle Live stating that he struggled early in the match, and Liverpool on their day are very fast starters.
They had scored twice in the first six minutes on the weekend, so Botman needs to be on his toes.
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Match Details
Where is the game being played?
The game is being played at Anfield in Liverpool, with a capacity of 54,074 supporters.
What time is kick-off?
Kick-off is at 20:00 BST.
How can I watch?
You can watch the game on BT Sport 1, coverage starts at 19:00 BST.
If you do not have access to BT Sport you can follow it live on VAVEL.com.