Despite beginning the new season relatively well, Wigan have endured some tough form as of late as they battle to survive in the Championship following promotion last season.
Leam Richardson's men are winless in four and have won just one in their previous seven games, a 1-0 victory over Blackburn Rovers last month.
The Latics' last outing saw Watford take home all three points from the DW Stadium with a 1-0 win, leaving their hosts in 21st position with 19 points.
Stoke City are on identical points and win, draw and loss records to their hosts on Wednesday, a sign that things have not gone as planned so far this season in North Staffordshire.
Alex Neil's side have not taken any points from their last three games, with a 3-1 loss at Norwich last time out only compounding their woes further.
The Potters also sit on 19 points, a place above Wigan in the table on goal difference.
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Team news
Wigan
An injury crisis has hit Leam Richardson's side in recent weeks, with goalkeeper Ben Amos the latest to be sidelined with a cracked rib that will see him out until after the World Cup.
The Latics are currently missing Charlie Wyke (hamstring), Ryan Nyambe (knee) and Callum Lang (ankle).
Tom Pearce is not yet fit after getting injured playing for the youth team last week.
Graeme Shinnie is unavailable after picking up his fifth booking of the season against Watford.
Stoke
Josh Tymon (ankle), Gavin Kilkenny (groin) and Dujon Sterling (ankle) are set to remain sidelined.
Tyrese Campbell missed his side's trip to Norfolk with illness, so is likely to return the matchday squad this week.
Harry Souttar has stepped up his recovery from a long-term ACL injury, playing a part in three u21 games in the last week.
He may play a part in the matchday squad but is unlikely to start a game yet.
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Likely lineups
Wigan
Jones (GK); Kerr, Whatmough, Tilt; Darikwa, Power, Cousins, Naylor, McClean; Keane, Broadhead.
Stoke
Bursik (GK); Clarke, Flint, Wilmot, Fox; Thompson, Baker, Powell; Fosu, Brown, Gayle.
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Ones to watch
Will Keane
Prolific in his days as a Manchester United youth player, Keane has played for six different EFL clubs throughout his career and struggled to find his feet at any before joining the Latics in 2020.
He fired 38 goals in 84 appearances in his first two seasons at the DW, winning the League One Golden Boot last season with 27 league goals last season. His recent form has seen him win four caps for the Republic of Ireland, and he has netted six in 16 games so far this season.
Jacob Brown
Despite an injury-hit season so far, Brown has proved his worth as one of City's most important players over the last 18 months as their go-to man for goals up front. Last season he hit 17 goals and assists in 45 Championship games as he earned his first call up to the Scotland national team.
He has only started nine games this term after struggling with a thigh problem and adapting to the change in manager. His two goals came in the first four games of the season before injury, but he is now fit and likely to be given another start at Wigan.
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Match details
Where is the game being played?
The game is being held at the DW Stadium in Wigan, Greater Manchester.
What time is kick off?
Kick off is at 19:45 BST, on Wednesday, November 2.
How can I watch?
The game will be televised on Sky Sports Red Button and Sky Go Extra.