The Foxes followed up their FA Cup heroics with a comfortable 3-0 win over relegation-threatened West Bromwich Albion on Thursday, and now find themselves needing 11 points from their last six games to confirm their spot in the UEFA Champions League next season.
Brendan Rodgers will be looking for his side to make another statement and record an important victory at the King Power Stadium, just like they were able to back in 2016.
Musa breaks Leicester duck
The season had been a difficult one to contend with for Leicester just one season on from their Premier League triumph.
Juggling a place in the Champions League alongside their league commitments, results and individual performances on the pitch hadn't been up to standard.
Summer signing from CSKA Moscow Ahmed Musa wasn't exempt from criticism. The Nigerian's time in the East Midlands was short-lived and largely underwhelming, however, he did show signs of encouragement with the game against the Eagles proof he could play a role.
The winger opened the scoring by both starting and finishing the move.
Running into the space, Musa found the feet of Islam Slimani who played a one-two with Shinji Okazaki before returning the ball to the number seven who rifled home from the edge of the box to score his first goal for the Foxes.
Okazaki doubles advantage
The former Japan international was a fan favourite during his time on Filbert Way and it was through his hard work that Leicester got their deserved second shortly after the hour mark.
Good work from the opening scorer Musa helped Okazaki slip Danny Drinkwater down the left channel as he looked to whip a ball into the Palace box.
Former Foxes defender Damien Delaney did his best to clear his lines but it wasn't enough as the ball only dropped as far as the on-rushing forward who drilled the ball low and hard past Steve Mandanda
Fuchs thunderbolt seals the points
Leicester's third of the afternoon was arguably the goal of the day and came courtesy of Christian Fuchs 10 minutes from time.
After the hosts corner was initially cleared away by the head of Christian Benteke, it was the Austrian full-back who reacted first, allowing the ball to bounce on the edge of the box.
In the right place at the right time, Fuchs hit the ball on the half-volley as it flew into the top corner and sent the crowd into raptures. The goal was Fuchs' first the club and first in three years since his strike for Schalke 04 at the Santiago Bernabeu against Real Madrid.
Yohan Cabaye found a late consolation for the visitors five minutes later, but it was too little too late as Claudio Ranieri's men sealed one of their most impressive victories of the season.