Juventus have had a dreadful start to their domestic season as they find themselves sitting in ninth place ten points behind league leaders Napoli.
Having comfortably dispatched Malmö by three goals to nil on matchday one Juventus will be hoping to repeat the feat against Chelsea on Wednesday, and will be hoping that their fans can make life very uncomfortable for the Chelsea players.
Chelsea meanwhile lost their first game of the season at the weekend against fellow title contenders Manchester City who put in a brilliant tactical performance to come away with a one-goal to nil victory at Stamford Bridge.
Like Juventus, Chelsea won their first match of the group stage beating a stubborn and resistant Zenit St Petersburg by one goal to nil. Chelsea will also know that if they can overcome Juventus it would give them total command of the group going into matchday 3.
Massimiliano Allegri was dealt a double blow at the weekend ahead of the Chelsea match with former Chelsea striker Alvaro Morata and Argentinian playmaker Paulo Dybala both set to miss out due to injuries they sustained against Sampdoria on Sunday.
Meanwhile, Thomas Tuchel has also got several injury concerns with defender Reece James likely to miss out after coming off the pitch against City on Saturday. However, Tuchel did receive a boost in that Mason Mount should be available to be included in the matchday squad with Christian Pulisic also maybe being involved.
Juventus: Szczesny, Cuadrado, Bonucci, De Ligt, Sandro, Locatelli, Bentancur, Bernadeschi, Chiesa, Keane, Kulusevski
Chelsea: Kepa, Silva, Christiansen, Rudiger, Chilwell, Azpilicueta, Jorginho, Kante, Lukaku, Havertz, Werner
Players to watch
With joint top scorers, Morata and Dybala injured Juventus will be looking to their midfield maestro to try and create and take opportunities against Chelsea on Tuesday.
Following his summer transfer from Sassuolo Manuel Locatelli has settled in very well at Juventus and has started every game for them so far this season as well as already scoring and providing an assist which finds him third on the top scorers list behind Morata and Dybala.
Although Juventus have been dealt a major blow with their two top scorers set to miss out, Chelsea will have to be wary of Locatelli and his ability to control the game in midfield.
While many people will talk about the impact Lukaku has had or the brilliance of Kante in midfield, one player that has gone under the radar is Antonio Rudiger.
Under Tuchel Rudiger has been constant and is almost always the first name of the team sheet. As well as him helping Chelsea keep clean sheets he is also instrumental in Chelsea's attack.
Rudiger often dribbles forward with the ball into the opposition's half and sometimes performs mesmerizing runs such as his run against Zenit on matchday one where he ran from his goal to Zenit's with no player able to touch him.
With the hostile atmosphere, Chelsea will be looking to Rudiger to provide calming influence on the team.
Last time out
The last time these two faced each other was in 2013 in the champions league group stages where Juventus ran out three-nil winners.
Juventus started the match quickly and nearly took the lead in the fourth minute. Stephan Lichtsteiner found himself free on the back post however he could not get the ball past Petr Czech who brilliantly diverted the ball onto the post.
Chelsea got their first chance six minutes later. Oscar broke through the Juventus defensive line and slid a ball through to Eden Hazard, however his shot only hit the side netting after a brilliant save from Gianluigi Buffon.
Juventus finally got the breakthrough in the 38th minute with Fabio Quagierella scoring the goal. Quagierella took a shot from long range and it took a deflection off a Chelsea player that flew past Czech who was unable to adjust himself in time.
Juventus continued to press for a second goal after halftime and finally 61st minute they got their second of the night. This time it's Arturo Vidal who scored the goal. Kwadwo Asamoah does brilliantly down the left-hand side of the pitch before cutting the ball back to Vidal on the edge of the Chelsea box who dispatched it clinically.
Juventus got the icing on the cake in the 90th minute when Sebastian Giovinco got their third goal. Giovinco broke past the Chelsea defense to leave himself one on one against Czech however, Giovinco was to fast and slotted past Czech into the bottom corner.
How to watch
Fans in the UK can tune into BT sport at 7 pm on Wednesday to catch the match however unfortunately the match will not be shown live in the US.